Pilot and Collaborative Translational and Clinical Studies (PCTCS)
The primary goal of the Pilot and Collaborative Translational and Clinical Studies (PCTCS) in the Delaware Valley Institute for Clinical and Translational Science (DVICTS) is to promote translational research across the T1-T3 research spectrum at the four DVICTS partner institutions – Thomas Jefferson University (TJU), the Nemours Alfred. I. duPont Hospital for Children (Nemours/AIDHC), Christiana Care Health System (CCHS) and the University of Delaware (UD). In doing so, DVICTS will foster training, education, and career development. It will also drive intellectual property development and private sector collaboration with its member institutions. In order to maximize the most creative opportunities for translational research, PCTCS intends to create new opportunities for building collaborations that span disciplines, institutions and generations within the DVICTS community.
PCTCS will catalyze the cultural shifts needed to foster collaborations in translational research in these four institutions by supporting a diverse portfolio of pilot programs. PCTCS will facilitate recruitment of skilled faculty and integration of new institutions, sustain their participation, and ensure their success in DVICTS. To accomplish these goals we propose an operational and management structure that will promote collaborations among researchers, practitioners, and communities across the Delaware Valley. The PCTCS will pursue the following three specific aims:
Currently funded DVICTS/DHSA Pilot Projects
"Novel Approaches to the Study of Determinant of Childhood Obesity utilizing Health Information Systems"
Deborah Ehrenthal, Kristin Maiden – CCHS, Judith Ross - TJU/Nemours, Samuel Gidding, David West, Lou Barteshesky – Nemours, Ben Carterette and Michael Peterson - UD
"Relationships between Cortical Motor Organization and Response to Exercise Interventions in Children with Cerebral Palsy"
Co-Investigators: Stuart Binder-McLeod, Samuel Lee, Trisha Kesar – UD, Freeman Miller – Nemours, Susan Duff – TJU and Kert Anzilotti – CCHS
"Linking Genotype to Phenotype: A pilot project to create a research data warehouse of biospecimen and omic information"
Co-Investigators: Jack London, TJU, Cathy Wu, UD, Ed Ewen, CCHS, and Timothy Bunnell, Nemours
"Discovery of inhibitors against the ubiquitin specific protease 11 in human DNA damage response"
Co-Investigators: Zhihao Zhuang, UD, Andrew Napper, Nemours, Jonathan Brody, TJU, and Zohra Ali-Khan Catts, CCHS
Previously funded DVICTS/DHSA Pilot Projects
"JAM-A - A Potential Risk Factor for Dilated Cardiomyopathy"
Co-Investigators: Ulhas P. Naik, UD, Takeshi Tsuda, Nemours, Walter Koch, TJU, and William Weintraub, Christiana Care
"Mechanisms of Castrate Resistant Prostate Cancer involving the Androgen Receptor in the Bone Microenvironment "
Co-Investigators: Robert Sikes, UD, Karen Knudsen, TJU, Ayyappan Rajasekaran, Nemours, and Charles Schneider, Christiana Care.